In step 3 fructose-6-phosphate is converted to fructose 1,6 bisphosphate by the enzyme phosphofructokinase (PFK-1). Phosphofructokinase is highly regulated inside the cell.
Why is step 3 the committed step in glycolysis?
Step 3 is an irreversible reaction whereas steps 1 & 2 are reversible, however, equilibrium of these first two reactions lie to the right in favor of the reaction going forward. The conversion of fructose-6-phosphate to fructose 1,6, bisphosphate commits the cell to carrying out glycolysis.
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