The last five reactions of glycolysis leads to production of two pyruvate molecules. The last five reactions are called the energy harvesting or energy payoff phase.
Reaction 6: Glyceraldehyde-P Dehydrogenase Reaction
G3P is converted to 1, 3 bisphosphoglycerate
This is the first reaction in glycolysis to generate a NADH molecule. NADH is an electron carrier that is used in the mitochondrion by the ETC to generate ATP.
Reaction 7: Phosphoglycerate kinase converts 1,3 BPG to 3-phosphoglycerate. It is the first step of glycolysis to generate ATP via substrate level phosphorylation. A phosphate group is removed from 1,3 BPG and transferred to ADP to form ATP (substrate-level phosphorylation).
Reaction 8: Phosphoglycerate mutase converts 3-phosphoglycerate to 2-phosphoglycerate.
What is the purpose of this reaction?
This rearrangement of the phosphate from the C-3 to C-2 position allows productio of phosphoenolpyruvate in the next reaction.
Reaction 9: Enolase converts 2-PG to PEP
Reaction 10: Pyruvate kinase converts PEP to pyruvate and also generates ATP via substrate level phosphorylation.
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